Existing 5-MeO-DMT studies have led early adopters to individually conclude that this psychedelic is non-addictive and sufficiently safe for their own occasional personal microdosing. It is up to each user to make this decision for themselves.
Based on general safety guidelines for vaping and for taking psychedelics, you should not be using the M-Pen:
5-MeO-DMT and Interactions with Medicines
5-MeO-DMT can be dangerous when taken in combination with certain medicines, including those that affect the serotonin system in the brain. Serotonin is a neurotransmitter involved in regulating mood, appetite, and other functions. When 5-MeO-DMT is taken with medications that also impact serotonin levels, the medicine may be dampened and there may be a risk of serotonin syndrome, a potentially life-threatening condition.
Some medications that may interact with 5-MeO-DMT and increase the risk of serotonin syndrome include:
Out of an abundance of caution, we have listed many medications and conditions at the end of this page. This information is intended as a reference only and should not be used as a sole basis for decision-making regarding medication interactions.
Consulting with Experts
It is strongly recommended that individuals consult with a qualified medical professional or relevant specialist before making any decisions about the concurrent use of medications.An expert on medications and 5-MeO-DMT is Dr. Ben Malcolm, aka the Spirit Pharmacist. He was trained as a clinical psychiatric pharmacist and worked in academia for almost five years before dedicating himself to plant medicines where he provides psychopharmacology consulting, courses in psychedelic pharmacy, and a Member Program. You can learn more and book a consultation with the Spirit Pharmacist here.
A trained Canadian expert is Dr. Trina Nguyen, aka the Dharmacist. Dr. Trina has two decades of formal pharmacy education and experience to facilitate new therapies that work. She can be consulted about pharmaceutical contraindications with 5-MeO-DMT, as well as other earth medicines. Dr. Trina operates solely on a donation-based model (Dāna), and can be contacted through her Dharmacist website.
Mental Health History or Conditions
The following mental health history or conditions are reasons to avoid taking 5-MeO-DMT:
List of Contraindicated Medicines
Please note that the list of drug contraindications provided below has been derived from The Spiritpharmacist’s Five Guide and should not be considered exhaustive or definitive. This information is intended as a reference only and should not be used as a sole basis for decision-making regarding medication interactions. It is strongly recommended that individuals consult with a qualified medical professional or relevant specialist before making any decisions pertaining to the concurrent use of medications.
Pseudoephedrine-containing products, including:
Medications that inhibit enzyme CYP2D6 including:
Monoamine Oxidase Inhibitors (MAOIs) including:
Selective Serotonin Reuptake Inhibitors (SSRIs) including:
Selective Serotonin Reuptake Inhibitors (SNRIs) including:
Serotonin Partial Agonist Reuptake Inhibitor (SPARIs) including:
Antipsychotics including:
Tricyclic Antidepressants (TCAs) including:
Weight loss agents, including:
Triptans (Migraine medications) including
Ergotamines (Migraine medications) including
Serotonin 3 receptor antagonists (Anti-nausea medications) including
Analgesics (Pain Relievers) including